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Learn More About Murali Doraiswamy
Brains are not failing us because people are living longer. They are failing because modern organizations still think about brain health as a late-life issue rather than a leadership issue. Dr. Murali Doraiswamy argues that the same forces reshaping work — artificial intelligence, constant cognitive overload, longer careers, and rising rates of burnout — are also redefining what it takes to sustain peak performance.
Professor of Psychiatry and Professor in Medicine at Duke University School of Medicine, Doraiswamy is one of the world’s leading physician-scientists studying the future of brain health, cognitive resilience, and human performance.
Doraiswamy’s work sits at the intersection of neuroscience, aging, and artificial intelligence. He has spent decades studying why some people and organizations maintain clarity, adaptability, and resilience under pressure while others decline. His research on neurocognitive disorders and Alzheimer’s disease has helped shape many of the diagnostic tools, clinical trials, and therapeutics now used in modern medicine. Increasingly, however, he focuses on what business leaders need to know before decline begins: how to build cognitive resilience, strengthen decision-making, and create workplaces that support sustained performance in an era of rapid technological change.
For executive audiences, Doraiswamy offers a distinctly practical message: the future of leadership depends on understanding the future of the human mind. He examines how AI will augment — and in some cases compete with — human cognition, and why organizations that invest in wellbeing, focus, and mental fitness will outperform those that continue to treat brain health as a personal issue rather than a strategic priority. His emerging work on “digital cognitive twins” and precision psychiatry gives leaders a glimpse into how AI-driven models may soon predict stress, burnout, and cognitive decline before they become organizational problems.
Murali Doraiswamy also brings unusual authority to conversations about aging workforces, healthcare, and longevity. In “The Alzheimer’s Action Plan: The Experts’ Guide to the Best Diagnosis and Treatment for Memory Problems” (2008), he translated leading-edge science into a practical roadmap for patients and families. Today, he helps healthcare systems, financial institutions, technology companies, and global employers think more broadly about what it means to protect human capability in a world where people will work longer, think alongside machines, and face unprecedented cognitive demands.
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Dr. Murali Doraiswamy is a Professor of Psychiatry and Behavioral Sciences and Professor in Medicine at Duke University School of Medicine, where he directs the Neurocognitive Disorders Program and serves as a senior fellow at the Duke Center for the Study of Aging and Human Development. He is Co-Chair of the World Economic Forum Global Future Council on Mental Health, a Fellow of the Royal College of Physicians in London, and a Fellow of the American Neurological Association. Doraiswamy has authored more than 400 scientific publications, advised organizations including the National Institutes of Health, the Food and Drug Administration, and the World Health Organization, and his work has been featured by the BBC, The New York Times, TIME, PBS, and Oprah.
Dr. Murali Doraiswamy is available to advise your organization via virtual and in-person consulting meetings, interactive workshops and customized keynotes through the exclusive representation of Stern Speakers & Advisors, a division of Stern Strategy Group®.
Wellbeing as a Driver of Peak Performance
Most organizations still treat employee wellbeing as a perk rather than a performance strategy. But according to Dr. P. Murali Doraiswamy, a leading physician-scientist at Duke University School of Medicine and former Co-Chair of the World Economic Forum’s Global Future Council on Mental Health, the science tells a different story: constant cognitive overload, longer careers, and rising burnout are silently eroding the decision-making and resilience organizations depend on most. Drawing on decades of clinical experience and neuroscience research and his advisory work with multiple government agencies, businesses and advocacy groups, Dr. Doraiswamy reveals why brain health is not a personal issue but a strategic priority — and why the organizations that invest in cognitive resilience will consistently outperform those that don’t. Audiences leave with a science-backed framework for building workplaces that sustain peak mental performance at every level.
How to Cognitively Thrive in the AI Era
As AI absorbs more of the analytical work that once defined leadership, a critical question emerges: what should humans be doing with their brains now? Dr. P. Murali Doraiswamy, a Duke University professor of psychiatry, neurology and former Chair of the World Economic Forum’s Global Council on Brain Research, whose career spans neuroscience and the application of AI in healthcare, argues that the AI revolution makes investing in human cognitive fitness more urgent, not less. In this presentation, he examines how AI will augment — and in some cases compete with — human cognition, and shares insights from his pioneering work on “digital cognitive twins” and precision psychiatry, which may soon predict stress and burnout before they become organizational crises. Audiences leave understanding how to protect and sharpen distinctly human capabilities in a world where people will work longer and think alongside machines.
Human Brain vs Machine Brain
Can a machine truly think the way a human does? According to Dr. P. Murali Doraiswamy—a Duke University professor who has spent decades studying the brain while simultaneously pioneering the use of AI in psychiatry and neurology—the answer is far more nuanced than most technology conversations allow, and understanding the difference is essential for any leader deploying AI. In this presentation, he takes audiences inside the architecture of the human brain—its capacity for intuition, emotional reasoning, and adaptability—and compares it with the pattern-recognition power and inherent limitations of today’s AI systems. Audiences leave understanding what machines do well, what only humans can do, and how leaders can build organizations that harness the best of both.
Longevity AI and the Future of the Mind
People are living and working longer than ever, but our understanding of how to sustain the mind across an extended career has not kept pace. Dr. P. Murali Doraiswamy, director of Duke University’s Neurocognitive Disorders Program and one of the world’s foremost Alzheimer’s researchers, has spent his career at this frontier. In this visionary presentation, he explores how advances in AI, precision psychiatry, and digital biomarkers are transforming our ability to detect cognitive decline years before symptoms appear—and how his emerging work on “digital cognitive twins” may soon allow organizations to monitor and protect cognitive health in real time. Audiences leave with a clear picture of where longevity science is headed and what leaders can do now to protect human capability in a world of longer careers and unprecedented cognitive demands.

The Alzheimer's Action Plan: The Experts' Guide to the Best Diagnosis and Treatment for Memory Problems
(St. Martin's Press, April 2008)
Individual bioenergetic capacity as a potential source of resilience to Alzheimer’s disease
(Nature Communications, February 24 2025)

Digital therapeutics for mental health: Is attrition the Achilles heel?
(Frontiers in Psychiatry, 2022)
Mobile and pervasive computing technologies and the future of Alzheimer’s clinical trials
(Nature, NPJ Digital Medicine, 2018)

Neuroimaging assessment of early and late neurobiological sequelae of traumatic brain injury: implications for CTE
(Frontiers in Neuroscience, 2015)










